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In vitro activity and mutagenicity of bisbenzylisoquinolines and quinones against Trypanosoma cruzi trypomastigotes

Identifieur interne : 00AB67 ( Main/Exploration ); précédent : 00AB66; suivant : 00AB68

In vitro activity and mutagenicity of bisbenzylisoquinolines and quinones against Trypanosoma cruzi trypomastigotes

Auteurs : A. Rojas De Arias [Paraguay] ; A. Inchausti [Paraguay] ; M. Ascurrat [Paraguay] ; N. Fleitas [Paraguay] ; E. Rodriguez [Paraguay] ; A. Fournet [France]

Source :

Phytotherapy Research [ 0951-418X ] ; 1994-05.

RBID : ISTEX:8213E9DB739B2C09BEC697644378C6EF8B044ED1

Descripteurs français

Wicri :
- topic : Transfusion sanguine.

English descriptors

Abstract

The accidental transmission of Chagas' disease by donor blood is recognized as a serious problem in the Latin America. This paper describes the screening of natural products as possible new chemoprophylactic additives in blood banks. Ten plant‐derived alkaloids, three terpenes, three quinones and 14 crude plant extracts were tested against bloodstream forms of Trypanosoma cruzi Y strain in vitro at 4°C at a concentration of 250 μg/mL, using gentian violet as the baseline drug. The bisbenzylisoquinoline alkaloids, cocsuline, daphnandrine, daphnoline, isochondodendrine, gyrocarpine, limacine and pheanthine and the naphthoquinone, plumbagin completely lysed the trypomastigote forms of T. cruzi at a concentration of 250 μg/mL, this activity was verified by the subculture of the treated medium during 4 months. The active alkaloids, pheanthine, daphnoline and limacine were evaluated for mutagenicity by the sister chromatid exchange assay (SCE) in peripheral lymphocytes. Daphnoline and pheanthine elicited no significant increase of the SCE up to 50 μg/mL, while limacine significantly increased the SCE values at a concentration of 25 μg/mL, and 50 μg/mL.

Url:

https://api.istex.fr/document/8213E9DB739B2C09BEC697644378C6EF8B044ED1/fulltext/pdf

DOI: 10.1002/ptr.2650080304

Affiliations:

France, Paraguay

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Le document en format XML

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<term>Bisbenzylisoquinoline alkaloids</term>
<term>Blood forms</term>
<term>Blood samples</term>
<term>Blood transfusion</term>
<term>Bloodstream forms</term>
<term>Chaga</term>
<term>Chromatid</term>
<term>Crude extracts</term>
<term>Crude plant extracts</term>
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<term>Final concentration</term>
<term>Fournet</term>
<term>Gentian</term>
<term>Gentian violet</term>
<term>Hocquemiller</term>
<term>Lavault</term>
<term>Limacine</term>
<term>Munnozia maronii</term>
<term>Mutagenicity</term>
<term>Natural products</term>
<term>Pera benensis</term>
<term>Peripheral lymphocytes</term>
<term>Pheanthine</term>
<term>Plantes medicinales boliviennes antiparasitaires</term>
<term>Plumbagin</term>
<term>Promastigote forms</term>
<term>Pure compounds</term>
<term>Significant increase</term>
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<term>Small health centres</term>
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<term>Trypanosoma</term>
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<front><div type="abstract" xml:lang="en">The accidental transmission of Chagas' disease by donor blood is recognized as a serious problem in the Latin America. This paper describes the screening of natural products as possible new chemoprophylactic additives in blood banks. Ten plant‐derived alkaloids, three terpenes, three quinones and 14 crude plant extracts were tested against bloodstream forms of Trypanosoma cruzi Y strain in vitro at 4°C at a concentration of 250 μg/mL, using gentian violet as the baseline drug. The bisbenzylisoquinoline alkaloids, cocsuline, daphnandrine, daphnoline, isochondodendrine, gyrocarpine, limacine and pheanthine and the naphthoquinone, plumbagin completely lysed the trypomastigote forms of T. cruzi at a concentration of 250 μg/mL, this activity was verified by the subculture of the treated medium during 4 months. The active alkaloids, pheanthine, daphnoline and limacine were evaluated for mutagenicity by the sister chromatid exchange assay (SCE) in peripheral lymphocytes. Daphnoline and pheanthine elicited no significant increase of the SCE up to 50 μg/mL, while limacine significantly increased the SCE values at a concentration of 25 μg/mL, and 50 μg/mL.</div>
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In vitro activity and mutagenicity of bisbenzylisoquinolines and quinones against Trypanosoma cruzi trypomastigotes

In vitro activity and mutagenicity of bisbenzylisoquinolines and quinones against Trypanosoma cruzi trypomastigotes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri